He Jiankui’s CRISPR Babies (2018): Chinese scientist He Jiankui shocked the world by announcing the birth of the first gene-edited babies, twin girls. Using CRISPR-Cas9, he modified the CCR5 gene in embryos to confer HIV resistance, despite the father being HIV-positive. The experiment was widely condemned for violating ethical norms, lacking transparency, inadequate informed consent, and posing unknown health risks. He bypassed regulatory oversight and peer review. The scientific community denounced the reckless human experimentation. He was later convicted by a Chinese court of illegal medical practice, sentenced to three years in prison, and fined. The long-term health effects on the children remain unknown, making this the most infamous gene editing scandal to date.
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