Allegations of Data Manipulation in Early CRISPR Studies: Shortly after CRISPR’s rise, concerns emerged about data integrity in foundational papers. Researchers, including those from major institutions, faced allegations of image manipulation in publications demonstrating CRISPR’s efficacy and specificity. Some studies were found to have duplicated or spliced gel images, potentially exaggerating results. While not all led to retractions, investigations by journals and institutions raised alarms about research rigor in the fast-moving field. The pressure to publish groundbreaking results may have compromised scientific standards. These incidents undermined trust and emphasized the need for reproducibility and transparency, especially when techniques like CRISPR are being developed for clinical applications where accuracy is paramount.
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