The Tuskegee Syphilis Study: From 1932 to 1972, the U.S. Public Health Service studied the progression of untreated syphilis in 600 African American men in Tuskegee, Alabama. Nearly 400 had the disease but were deliberately left untreated, even after penicillin became the standard cure in the 1940s. Participants were misled, told they were receiving free healthcare for "bad blood." The study aimed to observe long-term effects, revealing deep racial biases in medical ethics. Exposed by a whistleblower in 1972, it led to public outrage, new regulations for human subject research, and a presidential apology in 1997, but left lasting distrust in the medical system among Black Americans.
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